C-reactive protein-mediated vascular injury requires complement.

C-reactive protein upregulates complement-inhibitory factors in endothelial cells.

BACKGROUND Because complement-mediated vascular injury participates in atherosclerosis and C-reactive protein (CRP) can activate the complement cascade, we sought to determine whether CRP affects the expression of the protective complement-inhibitory factors on the cell surface of endothelial cells (ECs). METHODS AND RESULTS Human coronary artery or human saphenous vein ECs were incubated wit...

Decay-accelerating factor attenuates C-reactive protein-potentiated tissue injury after mesenteric ischemia/reperfusion.

BACKGROUND C-reactive protein (CRP) is an acute pro-inflammatory mediator that has been demonstrated to enhance ischemia/reperfusion (IR) injury by virtue of activating the complement system. CRP is able to interact with complement proteins such as C1q, complement factor H, and C4b-binding protein. Since complement activation is central in the expression of tissue injury following IR, we have i...

A Comparative Study of Serum Level of Vascular Cell Adhesion Molecule-1 (sVCAM-1), Intercellular Adhesion Molecule-1(ICAM-1) and High Sensitive C - reactive protein (hs-CRP) in Normal and Pre-eclamptic Pregnancies

Oxygen radicals mediate endothelial cell damage by complement-stimulated granulocytes. An in vitro model of immune vascular damage.

During hemodialysis, alternative pathway complement activation leads to pulmonary sequestration of granulocytes, with loss of pulmonary vascular endothelial integrity and, at times, protein-rich pulmonary edema. An in vitro model of this phenomenon was constructed utilizing 51Cr-labeled human umbilical vein endothelial cell cultures. In this system, granulocytes, when exposed to activated compl...

Corrigendum notice: Comparing the effect of 6 weeks of resistance training with and without vascular occlusion, on C-reactive protein and lactate dehydrogenase levels in active girls

  Corrigendum notice: Comparing the effect of 6 weeks of resistance training with and without vascular occlusion, on C-reactive protein and lactate dehydrogenase levels in active girls                Mahsa Porsesh *1, Abdolhamid Habibi2, Saeed Ahmadi Barati3, Seyed Reza Fatemi4                1-3Department of Sport Physiology, Faculty of Physical Education and Sports Sciences, Shahid Ch...